Nuclear sphingosine 1‐phosphate and lung cancer (96.3)
نویسندگان
چکیده
منابع مشابه
Dmd056622 963..973
Isoniazid (INH) treatment can cause serious liver injury and autoimmunity. There are now several lines of evidence that INHinduced liver injury is immune mediated, but this type of liver injury has not been reproduced in animals, possibly because immune tolerance is the dominant response of the liver. In this study, we immunized mice with isonicotinic acid (INA)-modified proteins and Freund’s a...
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Hypoxia and signaling via hypoxia-inducible factor-1 (HIF-1) is a key feature of solid tumors and is related to tumor progression as well as treatment failure. Although it is generally accepted that HIF-1 provokes tumor cell survival and induces chemoresistance under hypoxia, HIF-1-independent mechanisms operate as well. We present evidence that conditioned medium obtained from A549 cells, incu...
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Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses. There is increasing evidence of a role for S1P receptors (e.g...
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In this issue of Rheumatology, Stolwijk et al. [1] evaluate the validity of the self-administered co-morbidity questionnaire (SCQ) developed with the aim of assessing co-morbidity in AS. The article could not have a better justification and timing. Rheumatologists have witnessed remarkable advances in the last decade regarding the management of rheumatic diseases, mainly in the field of measure...
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Background. Cardiovascular disease is still portrayed as a typical male disease, and men are more often submitted to invasive procedures or referred earlier. Aim. To explore sex differences in morbidity and referral patterns in cardiovascular disease in general practice, and the role of age and socioeconomic status. Method. Data were obtained from a continuous morbidity registration project in ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.96.3